Earlier this week, the star 49ers receiver removed the 49ers profile photo on his Instagram profile, and unfollowed the team on the popular social media platform. 

Samuel is also set to enter the final year of his rookie contract in 2022, and from all accounts, contract extension talks aren't going all that well between him

All of the above could lead to a parting of ways between the two sides before the start of the 2022 campaign.

If such occurs, the Detroit Lions would be smart to put in a call to San Francisco for the former South Carolina Gamecocks wideout.

Samuel has been nothing but productive since entering the league, with his best season as a pro having come a year ago.

In 2021, the all-purpose yard phenom racked up 1,405 receiving yards and six touchdown catches, to go along with 365 rushing yards and eight TDs on the ground

He also averaged an impressive 6.58 yards per rushing attempt, including 4.11 yards before contact per attempt and 2.67 yards after contact.

The standout campaign from Samuel earned him a Pro Bowl nod and first-team All-Pro honors.

The Rundown: Cubs Start Season with W, Hendricks Outduels Burnes,